Metabolic Foundations of Health and Disease is a three-week course that provides a fundamental understanding of medical biochemistry related to the metabolism of lipids, carbohydrates, amino acids, and nucleotides with special emphasis on defects in these metabolic pathways and their clinical relevance. Special emphasis is placed on the integration of metabolic pathways and the regulation of metabolism in different organ systems under different nutritional stress. The course also provides insight into ethanol metabolism as well as the formation of reactive oxygen species and the potential tissue damage associated with oxygen radical formation. Clinical cases are presented in a team-based learning format to provide reinforcement of basic science concepts as they relate to clinical applications.