Genetic and Metabolic Disorders is a five-week course that provides a fundamental understanding of medical biochemistry relevant to the metabolism of macromolecular precursors and the genetic basis of disease. Medically-important metabolism of amino acids, lipids, and nucleotides, will be covered in the context of disease. The course also provides insight into ethanol metabolism and tissue damage associated with reactive oxygen species. Clinical disorders that have a genetic component will be covered, while a molecular framework is built for understanding disease etiology, modern diagnosis and therapeutic intervention. An overview of the basic genetics of medically important infectious agents, gene regulation, and population genetics will provide a background on the genetic underpinnings of human disease.