Musculoskeletal system provides a fundamental understanding of musculoskeletal basic science principles, and the application of this knowledge. The five-week course covers normal features and pathological processes of the musculoskeletal system and integument including embryology, anatomy, histology, biochemistry, genetics, physiology, microbiology, immunology, pathology, pharmacology, and therapeutics. Human gross anatomical dissection is an integral component of the course that facilitates the students understanding of anatomical structure/function relationships. Clinical cases are presented in a team-based learning format to provide reinforcement of basic science concepts as they relate to clinical applications. Students gain additional experience in teaching their peers in this course.