Systems Regulation is a three-week course that provides a fundamental understanding of molecular and physiologic processes that regulate the activity of multiple organ systems.  Cellular transport of ions and molecules is introduced, emphasizing genetic and microbial diseases that interfere with the normal function of transporters. The principle of homeostasis is defined at the level of cells, tissues, organs, and the whole body, with examples to demonstrate the importance of homeostasis in the control of body function. The autonomic nervous system is described in detail and then employed as the starting point for teaching of the foundations of human pharmacology. Pharmacological principles outlined include pharmacodynamics, pharmacokinetics, and toxicity. The course introduces the immune system, and then expands on the systemic role of inflammation in disease.