Molecular Foundations of Health and Disease is a three-week course that provides a fundamental understanding of the physiologic basis for macronutrient metabolism including the types of macromolecules that are metabolized to fuel, and physiologic states that alter macronutrient requirements such as starvation, trauma, and metabolic syndrome. The metabolism of glucose, generation of energy from glucose in the form of ATP, the hormonal regulation of glucose homeostasis, and consequences of defective glucose regulation that result in diabetes serve as the central content theme throughout the course. The course provides an introduction to anatomy, genetics, biochemistry, and pharmacology. Clinical cases are presented in a team-based learning format to reinforce basic science concepts as they relate to clinical applications.